Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment.

CONCLUSIONS: Our results provide novel insight into the mechanisms of a previously unrecognized pathway coupling coagulation to PDAC immune evasion by identifying PAR1-dependent changes in the tumor microenvironment, a PAR1-driven immunosuppressive gene signature, and Csf2 and Ptgs2 as critical PAR1 downstream targets.
PMID: 33064371 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - October 16, 2020 Category: Hematology Authors: Schweickert PG, Yang Y, White EE, Cresswell GM, Elzey BD, Ratliff TL, Arumugam P, Antoniak S, Mackman N, Flick MJ, Konieczny SF Tags: J Thromb Haemost Source Type: research