Acute Effect of an Inhaled Glucocorticosteroid on Albuterol-induced Bronchodilation in Patients with Moderately Severe Asthma.

CONCLUSIONS: This pilot study showed that in adult asthmatics with airflow obstruction, a single standard dose of an ICS can acutely increase the FEV1 response to a standard dose of inhaled albuterol administered simultaneously. The associated potentiation of albuterol-induced vasodilation in the airway was of greater magnitude and retained when the ICS was administered 30 min before albuterol. The clinical significance of this observation will have to be established by a study involving a larger patient cohort. PMID: 25611803 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research