New approaches for antituberculosis leads from Actinobacteria.

New approaches for antituberculosis leads from Actinobacteria. Drug Discov Today. 2020 Oct 15;: Authors: Hussain A, Hassan QP, Shouche YS Abstract Bioactive metabolites derived from the phylum Actinobacteria represent many of the existing antimicrobial drugs. Compared with other bacterial pathogens, direct preliminary screening by diffusion assays is a limiting factor against Mycobacterium tuberculosis (Mtb) and different methodologies have been used to improve the search for new molecules. However, the concern remains that most of the previously discovered molecules replicate by conventional procedures. However, the combination of multidisciplinary approaches with new technologies could advance the discovery of new leads in bacteria other than Mtb, such as the unexplored Actinobacteria. PMID: 33069935 [PubMed - as supplied by publisher]
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research