The “round the houses” sign and “zig-zag” sign in progressive supranuclear palsy and other conditions

We read with interest the recent correspondence by Abate et al. in which they described and coined the “zig-zag” sign in progressive supranuclear palsy (PSP) [1]. We have similarly noticed multiple patients with PSP undertaking a wandering or serpiginous route to vertical saccades. The sign, which consists of multiple slow oblique saccades in apparently random alternating directions, differs from Quinn's original description of the “round-the-houses” sign wherein vertical saccades in PSP traverse a single curved arc in the setting of largely preserved range of vertical gaze [2].

Source: Parkinsonism and Related Disorders - October 19, 2020 Category: Neurology Authors: Conor Fearon, Robert Field, Eoghan Donlon, Olwen C. Murphy, Simon Cronin, Cliona Buckley, Laura Williams, Yudy Llamas, Sean O'Dowd, Sean S. O'Sullivan, Daniel R. Gold, Daniel R. Gold, Richard Walsh, Daniel G. Healy, Niall Quinn, Timothy Lynch Tags: Correspondence Source Type: research