A Mechanism of Cocaine Addiction Susceptibility Through D2 Receptor –Mediated Regulation of Nucleus Accumbens Cholinergic Interneurons

People with addiction differ from casual drug users by their uncontrollable drug intake despite the adverse consequences associated with drug use. The compulsive drug-seeking and drug-taking behaviors that define addiction are also observed in rodent models that were first established almost 2 decades ago. Studies have shown that there is a percentage of individuals in human and rodent populations that are susceptible to drug use while others are resilient (1,2). Susceptibility to developing any substance use disorder is influenced by genetic and epigenetic variation along with psychosocial factors.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research