Polymorphisms of the μ‐opioid receptor gene influence cerebral pain processing in fibromyalgia

ConclusionsG ‐allele carriers showed increased activation in PCC/precentral gyrus but decreased functional connectivity with the frontal control network during pressure stimulation, suggesting different pain modulatory processes between OPRM1 genotypes involving altered fronto‐parietal network involvement. F urthermore, our results suggest that the overall effects of the OPRM1 G‐allele may be driven by FM subjects.

Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Isabel Ellerbrock, Angelica Sandstr öm, Jeanette Tour, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Eva Kosek Tags: ORIGINAL ARTICLE Source Type: research