A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection

Conclusions: This systematic review delineates and summarizes clinical features, management, and outcomes of MIS-C associated with SARS-CoV-2 infection. Although most children required intensive care and immunomodulatory therapies, favorable outcomes were reported in the majority with low-mortality rates.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research

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An alarming increase in children presenting with fever, hyperinflammation, and multiorgan dysfunction frequently requiring intensive care has been observed after severe acute respiratory syndrome coronavirus 2 infection. The illness resembles Kawasaki disease (KD), with coronary dilatation and aneurysm occurring in some. However, the cardiovascular manifestations were typically on the severe end of the KD spectrum, with cardiogenic shock a common presentation together with other features. This led to defining a unique syndrome named multisystem inflammatory syndrome in children (MIS-C). In this issue of the JCI, Lee and Da...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: Bertoli F, Veritti D, Danese C, Samassa F, Sarao V, Rassu N, Gambato T, Lanzetta P Abstract The novel pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has challenged the medical community. While diagnostic and therapeutic efforts have been focused on respiratory complications of the disease, several ocular implications have also emerged. SARS-CoV-2 RNA has been found in tears of the infected patients, and reports suggest that the ocular surface could serve as a portal of entry and a reservoir for viral transmission. Clinically, COVID-...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Kaushik et al provide a comprehensive overview of characteristics of the multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (1) All 33 children had evidence of SARS-CoV-2 infection in the form of positive reverse-transcription polymerase chain reaction and/or positive antibody test (1). Similar to routine (non-SARS-CoV-2 related) Kawasaki disease , the commonest treatment modality employed was intravenous immunoglobulin (IVIg).
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
Conclusions: Pediatric COVID-19 and its potential association to severe KD, still unfamiliar to heal th professionals, reinforces the importance of testing patients with vasculitis for the new coronavirus and the need to wage high surveillance and preparation of the health system during the current pandemic.RESUMO Objetivo: Analisar a literatura cient ífica atual a fim de documentar, por meio de revisão integrativa, os principais achados que associam a doença de Kawasaki (DK) à doença do coronavírus (COVID-19). Fonte de dados: A busca ocorreu em junho de 2020, nas bases de dados: B...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
rapcak S, Datta D, Morris SB, Clarke K, Belay E, California MIS-C Response Team Abstract In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the virus that causes COVID-19 (1). The clinical signs and symptoms present in this fir...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
We describe a patient with critical illness consistent with atypical Kawasaki disease with cardiac dysfunction and abdominal involvement presenting weeks after Severe Acute Respiratory Syndrome Coronavirus 2 infection. Our patient showed unique central nervous system involvement with small vessel vasculitis and profound hypocomplementemia, both not previously reported in case descriptions and may hint at possible disease mechanisms.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
We read with interest the well-founded observation made by Yung et al regarding no change in epidemiology or cases of Kawasaki disease in Singapore amid the current ongoing SARS-Coronavirus-2 pandemic. When it was initially recognized, there was uncertainty whether the SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C) represented Kawasaki disease. Evidence and evolving understanding suggest it to be a separate clinical entity.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
Recent reports in several medical journals, including JAMA, and the general media have highlighted the emergence of coronavirus disease 2019 (COVID-19) –associated inflammatory syndromes in children. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to induce this new condition, which has been called pediatric multisystem inflammatory syndrome (PIMS) or pediatric multisystem inflammatory syndrome temporally associated with SARS -CoV-2 (PIMS-TS) and described in detail by investigators in Europe and New York, New York. Additionally, investigators in Italy have reported a dramatic surge in Kawasaki d...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
Authors: Rajapakse N, Dixit D Abstract Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute resp...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
CONCLUSION: HScore can be used as a complement to clinical decision for initiating immunosuppression. Children with moderate-to-severe COVID-19, especially those with documented thrombocytopenia or chilblains, should be regularly monitored for coagulopathy. PMID: 32583809 [PubMed - as supplied by publisher]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
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