Pharmacokinetics and Biodistribution of Tacrolimus after Topical Administration: Implications for Vascularized Composite Allotransplantation

ConclusionTopical application of TAC ointment (Protopic ®, 0.03%) at a dose of 0.5 mg/kg/day provided high concentrations in the local tissues with low systemic exposure. Repeated topical administration of TAC is well tolerated with no local or systemic adverse effects. This study confirms the feasibility of topical application of TAC for site specific graft immunosuppression and enables future applications in VCA.

http://link.springer.com/10.1007/s11095-020-02921-w

Source: Pharmaceutical Research - October 16, 2020 Category: Drugs & Pharmacology Source Type: research