Modelling multiple sclerosis using induced pluripotent stem cells
Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy. In this review, the challenges related with the use of iPSC-derived cells in MS are discussed, with a special focus on the functional studies performed, limitations and future perspectives.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: J Ășlia MartĂnez-Larrosa, Clara Matute-Blanch, Xavier Montalban, Manuel Comabella Tags: Review Article Source Type: research
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