Top medicine articles for January 2015
A collection of some interesting medical articles published recently:Nearly half of high school students had ever tried tobacco in 2013, and nearly a quarter were current users http://buff.ly/1xw5dCeEvery Kiss Begins With 80 Million Germs – study published in journal Microbiome. Kissing is a courtship behavior unique to humans and is common in over 90% of known cultures http://buff.ly/1qoEsxyGeneric Versions of ADHD Drug Concerta Not Therapeutically Equivalent - FDA http://buff.ly/1qNSCCUColors used in tattoo ink need to be absolutely water-insoluble. That alone makes them a health risk. Only two thirds of the ink used in a tattoo stays in the skin. The other one third spreads through the body. "Tattoo ink migrates into the blood, lymph nodes, organs. Nobody knows where exactly or what happens with it." Red tattoo pigment 22 may decompose in sunlight. The resulting compounds are toxic and can cause cancer. Phthalocyanines make blue or green tattoos, contain metals such nickel, which can cause contact dermatitis. 25% of Americans have tattoos. However, "Tattoo colors are not really safe at the moment", say experts http://buff.ly/1vto5ldThree tropical diseases—dengue, chagas, and chikungunya—may establish U.S. footholds. Chagas disease spreads in a particularly "disgusting" way: by kissing bugs that bite people's faces at night. Chagas affects approximately 300,000 people in the U.S., though other estimates run as high as one mill...
Publication date: Available online 1 June 2020Source: MethodsAuthor(s): Reyhaneh Manafi-Farid, Najme Karamzade-Ziarati, Reza Vali, Felix M. Mottaghy, Mohsen Beheshti
Publication date: Available online 2 June 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Dipanwita Das Mukherjee, N. Maruthi Kumar, Mukund P. Tantak, Satabdi Datta, Debabrata Ghosh Dastidar, Dalip Kumar, Gopal Chakrabarti
Authors: Barber MRW, Clarke AE Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. AREAS COVERED: This narrative review provides an overview of rec...
Th17 cells (producing IL-17) and Th9 cells (producing IL-9) exhibit functional plasticity, and their role in tumorigenicity is controversial. Th17/IL-17 and Th9/IL-9 exhibit critical, but often opposing, roles in tumor progression. In this issue of the JCI, Salazar et al. show that while IL-17 and IL-9 induced distinct but complementary molecular pathways, both cytokines also induced epithelial-mesenchymal transition (EMT) in lung cancer cells and promoted metastatic spreading. A key question before us now is whether IL-9 and IL-17 contribute to tumor progression in a sequential and stage-specific manner within the tumor microenvironment.
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with terminal cancer suffer from cancer pain as a result of bone metastasis and bone destruction, but how PD-1 blockade affects bone cancer pain remains unknown. Here, we report that mice lacking Pdcd1 (Pd1−/−) demonstrated remarkable protection against bone destruction induced by femoral inoculation of Lewis lung cancer cells. Compared with WT mice, Pd1−/− mice exhibited increased baseline pain sensitivity, but the deve...
In conclusion, Th9 and Th17 lymphocytes induce lung cancer cell EMT, thereby promoting migration and metastatic spreading and offering potentially novel therapeutic strategies.
Letter to the editor regarding "Potential for prevention: a cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme". Scand J Gastroenterol. 2020 Jun 01;:1-2 Authors: Thomsen MK, Støvring H, Mikkelsen EM PMID: 32479193 [PubMed - as supplied by publisher]
Publication date: Available online 1 June 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Hyun Jeong Won, Akhmad Irhas Robby, Hee Sauk Jhon, Insik In, Ji Hyun Ryu, Sung Young Park
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00879F, PaperVipan Kumar, Bharvi Sharma, Liang Gu, Ruvesh Pascal Pillay, Nosipho Cele, Paul Awolade, Parvesh Singh, Mandeep Kaur A series of 1H-1,2,3 triazole grafted tetrahydro- β-carboline-chalcone/ferrocenylchalcone conjugates were synthesized and invitro evaluated against Estrogen Responsive (MCF-7) and Triple Negative (MDA-MB-231) breast cancer cells. Comparative analysis revealed the improvement of... The content of this RSS Feed (c) The Royal Society of Chemistry
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