Aquagenic (pseudo) keratoderma (aquagenic palmoplantar keratoderma, aquagenic wrinkling of palms)

Aquagenic (palmoplantar) keratoderma (APK) is an uncommon hereditary or sporadic condition which is characterized by edematous flat-topped papules appearing on palmar skin with wrinkling after brief water exposure. APK has been associated with cystic fibrosis (CF), presenting with the same mutations found in CF (usually ΔF508 of the CFTR gene), either homozygous or heterozygous. APK may be idiopathic or drug-induced. The diagnosis is easily made, if one is aware of this entity. Topical aluminum hydroxide and botulinum toxin injections are the most commonly used treatments.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research