Pulmonary Hypertension Associated with Bronchiolitis Obliterans after Stem Cell Transplant

Bronchiolitis obliterans (BO) and pulmonary hypertension (PH) are rare and fatal complications of stem cell transplantation (SCT). BO is a non-reversible obstructive lung disease in which bronchioles are compressed and narrowed by fibrosis and/or inflammation. PH arises from increased pulmonary vascular resistance leading to increased right ventricular pressure, right heart failure, and death. PH has not been described in patients with BO after SCT.

Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Christopher E. Dandoy, Abigail Pate, Mikako Warren, Kasiani C. Myers, Javier El-Bietar, Alexandra Filipovich, Russel Hirsch, Ranjit Chima, Stella M. Davies, Sonata Jodele Tags: Pediatric Disorders Source Type: research