[Melanoma : Introduction and special demands on radiology.]

[Melanoma : Introduction and special demands on radiology.]
Radiologe. 2015 Jan 23;
Authors: Schiller M, Hassel JC
Abstract
CLINICAL ISSUE: The incidence of melanoma has rapidly increased in the last decades. Most relevant for patient prognosis is the tumor thickness, hence an early diagnosis is crucial.
STANDARD TREATMENT: The basis of treatment is at the primary tumor stage and excision of regional metastases with curative intention.
TREATMENT INNOVATIONS: Targeted therapies, such as BRAF and MEK inhibitors have the advantage of a rapid response even in highly advanced stages of the disease.
DIAGNOSTIC WORK-UP: For routine diagnostics ultrasound, computed tomography (CT), fluorodeoxyglucose positron emission tomography CT (FDG-PET/CT) and magnetic resonance imaging (MRI) are used.
PERFORMANCE AND ACHIEVEMENTS: In the treatment of distant metastases new treatment options are available which more than doubled patient survival rates. Especially immune therapies with immune checkpoint blockers, such as ipilimumab or PD-1 antibodies can lead to long-term survival of patients. In contrast to chemotherapy these new substances have characteristics which make new demands on radiologists related to the possibility of pseudoprogression in immune therapies, which make it necessary to use other response criteria. In addition, autoimmune phenomena, such as a sarcoid-like reactions may mimic new metastases and shou...

Source: Der Radiologe - January 23, 2015 Category: Radiology Authors: Schiller M, Hassel JC Tags: Radiologe Source Type: research