Laboratory Variability in the Diagnosis of Type 2 VWD Variants.

CONCLUSIONS: Both the prospective and retrospective cohorts demonstrated consistent variation in subjects whose diagnosis changed between 2A, 2B, and 2M. The importance of accurately diagnosing type 2 VWD may be most significant in the 2B subtype given potential concerns with the use of desmopressin in type 2B VWD. Some genetic variants appear in multiple types of VWD, making specific diagnoses challenging.
PMID: 33049112 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - October 13, 2020 Category: Hematology Authors: DiGiandomenico S, Christopherson PA, Haberichter SL, Abshire TC, Montgomery RR, Flood VH, Zimmerman Program Investigators Tags: J Thromb Haemost Source Type: research