MiR-146a rs2910164 G & gt; C polymorphism modulates Notch-1/IL-6 signaling during infection: a possible risk factor for Crohn’s disease

ConclusionsThe data clearly associates miR-146ars2910164 GC with an overactive immune response and increases the risk to acquire infection. The study is even more relevant now in our efforts to understand susceptibility to SARS-CoV-2 infection and the development of COVID-19. This study suggests that genetic variations among COVID-19 patients may predict who is at a higher risk of acquiring infection, developing exacerbating symptoms, and possibly death. A high scale study with more clinical samples from different disease groups is planned.

http://link.springer.com/10.1186/s13099-020-00387-0

Source: Gut Pathogens - October 15, 2020 Category: Microbiology Source Type: research