Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells.

CONCLUSIONS: Higher PFN2 expression is associated with a worse 10-year overall survival and relapse-free survival in breast cancer patients, as well as worse 10-year relapse-free survival in TNBC patients. PFN2 promotes the proliferation, migration and invasion of TNBC cells by regulating epithelial-to-mesenchymal transition.
PMID: 33047272 [PubMed - as supplied by publisher]

Source: Breast Cancer - October 12, 2020 Category: Cancer & Oncology Authors: Ling Y, Cao Q, Liu Y, Zhao J, Zhao Y, Li K, Chen Z, Du X, Huo X, Kang H, Chen Z Tags: Breast Cancer Source Type: research