Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV

Conclusions
Among virologically suppressed PWH, nucleic acid oxidation was associated with standard CSF biomarkers of neurodegeneration. Potential sources of oxidative stress in PWH include low-level HIV replication, inflammation, mitochondrial dysfunction, and specific antiretroviral drugs. Results suggest that the higher levels of oxidative stress among PWH may play a role in neurodegeneration.

Classification of evidence
This study provides Class II evidence that among virologically suppressed PWH, nucleic acid oxidation is associated with standard CSF biomarkers of neurodegeneration.

Source: Neurology Neuroimmunology and Neuroinflammation - October 14, 2020 Category: Neurology Authors: Ellis, R. J., Moore, D. J., Sundermann, E. E., Heaton, R. K., Mehta, S., Hulgan, T., Samuels, D., Fields, J. A., Letendre, S. L. Tags: HIV Article Source Type: research