Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents.

This article provides an overview of the discovery and development of small-molecule antagonists of PAR4 as novel antiplatelet agents, including structure-activity relationship (SAR) analysis, progress of structure and bioassay optimization, and the latest structural and/or clinical information of representative small-molecule antagonists of PAR4. PMID: 33049608 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33049608?dopt=Abstract

Source: European Journal of Medicinal Chemistry - October 7, 2020 Category: Chemistry Authors: Liu S, Li S, Yuan D, Wang E, Xie R, Zhang W, Kong Y, Zhu X Tags: Eur J Med Chem Source Type: research