Pathological manifestation of autoimmune myocarditis is detected prior to glomerulonephritis in a murine model of lupus nephritis.

CONCLUSIONS: Histopathology, functional abnormalities, and enhanced cMRI signals indicative of myocarditis are detected in NZM2410 mice without glomerulonephritis, which supports the primary pathological role of autoimmune-mediated, cardiac-targeted inflammation in lupus.
PMID: 33045900 [PubMed - as supplied by publisher]

Source: Lupus - October 12, 2020 Category: Rheumatology Authors: Young NA, Jablonski K, Schwarz E, Okafor I, Hampton J, Valiente GR, Henry C, Harb P, Barger J, Bratasz A, Kalyanasundaram A, Ardoin SP, Jarjour WN Tags: Lupus Source Type: research