Total chemical synthesis of the phosphorylated p62 UBA domain reveals that Ser407Pi but not Ser403Pi enhances ubiquitin binding

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01906B, PaperLing Xu, Yan Zhang, Yi-Ming Li, Xian-Fu Lu As an autophagic adaptor, p62 specifically targets ubiquitinated proteins to the autophagosome for lysosomal degradation through a critical ubiquitin-associated (UBA) domain. Recent researches reported that Ser403 and Ser407 sites on... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - October 14, 2020 Category: Molecular Biology Authors: Ling Xu Source Type: research