Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus

ConclusionsDecreased NO bioavailability plays an important role in the progression of such macrovascular diseases as diabetes. BH4 levels decrease in diabetes patients, while the increased gene expression of GCHI reverses the diabetes-related BH4 deficiency and allows the endothelial cells to regain their ability to produce NO. Since GCHI is the rate-limiting enzyme in the biosynthesis of BH4, changes in GCHI levels directly affect the BH4 levels and the NO metabolism, leading to an increased risk of macrovascular complications. The significant increase in neopterin levels suggest that this is a potential biomarker for the early diagnosis of GDM.

Source: Journal of Diabetes and Metabolic Disorders - October 13, 2020 Category: Endocrinology Source Type: research