The Cryo-immunologic effect: a therapeutic advance in the treatment of glioblastomas?

The Cryo-immunologic effect: a therapeutic advance in the treatment of glioblastomas?
Neurochirurgie. 2020 Oct 09;:
Authors: Cebula H, Noel G, Garnon J, Todeschi J, Burckel H, DeMathelin M, Gangi A, Proust F
Abstract
The immunotherapy of cerebral glioblastoma has become a hot topic. Immune checkpoint blockade antibodies have progressively acquired a role in the management of malignant tumors. A multimodal approach using surgery, radiotherapy, chemotherapy in combination with immunotherapy represent a potent weapon against glioblastomas. In parallel, clinical applications of cryotherapy - freezing tumors based on repetition of rapid freeze-slow thaw cycle - for various cancers such as skin, lung, breast, esophagus, hepatic, kidney, prostate and bone tumors were developed. The future immunomodulatory approaches might be combined with brain tumors cryoablation to increase the cryoimmune response.
PMID: 33045247 [PubMed - as supplied by publisher]

Source: Neuro-Chirurgie - October 9, 2020 Category: Neurosurgery Authors: Cebula H, Noel G, Garnon J, Todeschi J, Burckel H, DeMathelin M, Gangi A, Proust F Tags: Neurochirurgie Source Type: research