Favorable changes of left ventricular function in the circumferential direction following transcatheter atrial septal defect closure: a strain imaging study

AbstractTo clarify the impact on left ventricular (LV) function of percutaneous atrial septal defect (ASD) closure in adult patients.  Echocardiograms of 46 patients (52 ± 18 years) who underwent ASD closure with a significant left-to-right shunt obtained before and 1 month after the procedure were retrospectively analyzed. Functional parameters were obtained by 2-dimensional speckle-tracking imaging. Global longitudinal st rain and strain rate at early diastole (SRe) was calculated from the three standard apical views, while circumferential and radial parameters were calculated from basal, middle, and apical LV short-axis views. Along with a diminished right ventricular (RV) volume, the LV volume and ejection fractio n increased (end-diastolic volume: 61 ± 12 to 76 ± 15 mL,p <  0.001; and 63% ± 4 to 64% ± 4%p = 0.03; respectively). Both global strain and SRe was augmented only in the circumferential direction (− 16.2% ± 2.9% to − 19.8% ± 2.8%; and 1.07 ± 0.29 to 1.34 ± 0.28 s−1, bothp <  0.001). Augmentation of circumferential SRe correlated with both the changes in and the pre-procedural value of diastolic LV eccentricity index (r = − 0.57,p <  0.001; andr = 0.37,p = 0.01; respectively), a morphological parameter of RV volume overload. Following ASD closure in adults, both LV systolic and diastolic function could favorably change in the circumferential direction, and the degree of diastolic fu...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research