Synthesis of Difluoroalkylated 2-Azaspiro[4.5]decanes Derivatives via Copper-Catalyzed Difluoroalkylation/ Dearomatization of N-Benzylacrylamides

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01833C, CommunicationChengwen Li, Yilin Zhao, Jiaxin Zhou, Xue Wang, jingli hou, Yuguang Song, Wenjuan Liu, Guifang Han An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes via copper-catalyzed difluoromethylation of N-benzylacrylamides with ethyl bromodifluoroacetate has been established. The reaction experienced a tandem radical addition, dearomatizating cyclization process.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research