Prophylactic foscarnet for human herpesvirus 6: effect on hematopoietic engraftment after reduced intensity conditioning umbilical cord blood transplantation
Umbilical cord blood (UCB) is a valuable alternative for allogeneic hematopoietic stem cell transplantation (HCT). However, delayed engraftment, graft failure, and increased risk for opportunistic infections remain major challenges when considering this donor source. Human herpesvirus-6 (HHV-6) reactivation occurs in the majority of UCB recipients.1-3 Thus, UCB recipients are a particularly vulnerable population for HHV-6 viremia and post-transplant complications with severe sequelae such as delayed hematopoietic recovery, graft failure, and limbic encephalitis.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Najla El Jurdi, John Rogosheske, Todd DeFor, Nelli Bejanyan, Mukta Arora, Veronika Bachanova, Brian Betts, Fiona He, Shernan Holtan, Murali Janakiram, Samantha Larson, Joseph Maakaron, Armin Rashidi, Erica Warlick, John E. Wagner, Jo-Anne H Young, Daniel Source Type: research