Effect of sodium acetate on serum activity of glucose-6-phosphate dehydrogenase in Plasmodium berghei -infected mice

This study, therefore, investigated the effect of sodium acetate on glucose-6-phosphate dehydrogenase inPlasmodium berghei-infected mice. Thirty male Albino mice were randomly distributed into 6 groups, A –F. Animals in Groups B–F were inoculated withP. berghei, intraperitoneally. Subsequently, Group C mice  were treated with 20 mg/kg chloroquine, while groups D, E and F received 25, 50 and 100 mg/kg sodium acetate, respectively. All treatments were administered orally for 4 days. At the end of the experiment, animals were sacrificed by cervical dislocation and blood was collected via cardiac pun cture for the analyses of serum glucose-6-phosphate dehydrogenase (G6PD), uric acid and lipid profile. Our results showed that Sodium acetate (50 and 100 mg/kg) significantly reduced (p <  0.05) parasitaemia (67.11% and 77.62%, respectively) than chloroquine (61.73%). Besides, body weight and serum G6PD activity inP. berghei infection were improved. Similarly, sodium acetate reduced elevated serum uric acid. Effects of sodium acetate and chloroquine on biochemical parameters were comparable (p >  0.05) but atherogenic lipid ratios were not affected by sodium acetate. These data put together suggested that activity of sodium acetate may be harnessed for development of novel anti-malaria drugs. However, more studies are required to delineate its mechanisms of action.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research