Inter/Intra-tumoral Dose Response Variations Assessed Using FDG-PET/CT Feedback Images: Impact on Tumor Control and Treatment Dose Prescription.

CONCLUSIONS: The study demonstrates that tumor dose response assessed using FDG-PET/CT feedback images had a similar distribution to those assessed conventionally using in vitro tumor clonogenic assay. Inter-tumoral dose response variation seems larger for HPV- tumors, but intra-tumoral dose response variations are similar for both HPV groups. These variations cause very large variation on the individual tumor control probability and limit the efficacy of dose escalation and de-escalation in conventional clinical practice. On the other hand, heterogeneous dose prescription guided by metabolic imaging feedback has a potential advantage in radiotherapy.
PMID: 33035624 [PubMed - as supplied by publisher]

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 6, 2020 Category: Radiology Authors: Yan D, Chen S, Krauss DJ, Deraniyagala R, Chen P, Ye H, Wilson G Tags: Radiother Oncol Source Type: research