Acetic Acid in Vinegar Kills Mesothelioma Cells

For more than 2,000 years, people have used vinegar to preserve and flavor food, disinfect wounds and treat a wide range of ailments, from stomach aches to diabetes. Yet modern scientists remain skeptical of these storied medicinal benefits, often dismissing vinegar-based treatments as folk remedies with questionable proof behind them. However, a recent study published in the December 2014 issue of Journal of Gastroenterology and Hepatology suggests this perception soon may change — especially when it comes to mesothelioma treatment. "Acetic acid is a powerful anticancer agent," wrote Susumu Okabe, lead author of the study. "Topical application of acetic acid may be a feasible approach for the treatments of gastric cancer and possibly other malignancies." Okabe’s team reached this conclusion after adding a low concentration of acetic acid to a Petri dish containing two mesothelioma cell lines cultivated from human patients. The study also explored the mild acid's effectiveness against stomach cancer, using cells from humans and mice models. When researchers increased the acid dose, a greater number of cancer cells died. Near Complete Cancer Cell Death Okabe and colleagues tested several concentrations of acetic acid, observing how cancerous and healthy cells responded over various intervals of time. A low concentration of 0.5 percent acid triggered an impressive anticancer effect on the two mesothelioma cell lines tested. Nearly all cancer ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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Publication date: Available online 16 August 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Jakub Kollar, Vladimir FrecerAbstractInhibitors of histone deacetylase superfamily (HDAC), which induce cell cycle arrest, trigger cell death and reduce angiogenesis appear as promising anti-cancer drugs targeting the epigenetic regulation of gene expression. Approved HDAC inhibitors were found effective against haematological and solid malignancies, other HDACIs are currently in clinical trials for the treatment of neurological diseases or immune disorders. Among those, diarylcyclopropane hydroxamic acids (DCHA) ...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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In this study, we tested whether catalpol has the potential to improve insulin sensitivity by augmenting myogenesis.Main methodsWe examined the hypoglycaemic mechanism of catalpol in db/db mice and C2C12 cells. db/db mice were treated with catalpol (200 mg/kg) for 8 consecutive weeks. Serum analysis, skeletal muscle performance and histology, and gene and protein expression were performed. In vitro glucose uptake, gene and protein expression were determined, and small interfering RNA was used to identify the underlying hypoglycaemic mechanism of catalpol.Key findingsIn this study, we tested whether catalpol has the poten...
Source: Life Sciences - Category: Biology Source Type: research
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Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
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