Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.

CONCLUSIONS: Genetic predisposition to depression may have positive causal roles on CAD/MI. Genetic susceptibility to self-awareness of mood problems may be a strong causal risk factor of CAD/MI. Blood lipid levels and smoking may potentially mediate the causal pathway. Prevention and early diagnosis of depression are important in the management of CAD/MI.
PMID: 33032663 [PubMed - as supplied by publisher]

Source: Psychological Medicine - October 9, 2020 Category: Psychiatry Authors: Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, Au PC, Sham PC Tags: Psychol Med Source Type: research