Interleukin-33 rescues perivascular adipose tissue anti-contractile function in obesity.

In conclusion, IL-33 treatment restored PVAT anti-contractile function in obesity, and reversed development of hypertension, hyperglycaemia, and hyperinsulinemia. These data suggest that targeting eosinophil numbers in PVAT offers a novel approach to the treatment of hypertension and type-2 diabetes in obesity.
PMID: 33035443 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Heart and Circulatory Physiology - October 9, 2020 Category: Physiology Authors: Saxton SN, Whitley AS, Potter RJ, Withers SB, Grencis RK, Heagerty AM Tags: Am J Physiol Heart Circ Physiol Source Type: research