Novel approaches to restore parasympathetic activity to the heart in cardiorespiratory diseases.

Novel approaches to restore parasympathetic activity to the heart in cardiorespiratory diseases.
Am J Physiol Heart Circ Physiol. 2020 Oct 09;:
Authors: Dyavanapalli J
Abstract
Neural control of the heart is regulated by sympathetic and parasympathetic divisions of the autonomic nervous system, both opposing each other to maintain cardiac homeostasis via regulating heart rate, conduction velocity, force of contraction and coronary blood flow. Sympathetic hyperactivity and diminished parasympathetic activity are the characteristic features of many cardiovascular disease states including hypertension, myocardial ischemia, and arrhythmias that result in heart failure. Restoring parasympathetic activity to the heart has recently been identified as the promising approach to treat such conditions. However, approaches that used vagal nerve stimulation have been shown to be unsuccessful in heart failure. This review focusses on novel chemogenetic approaches used to identify the cardioprotective nature of activating neural points along the vagal pathway (both central and peripheral) while being selectively therapeutic in heart failure and obstructive sleep apnea.
PMID: 33035444 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Heart and Circulatory Physiology - October 9, 2020 Category: Physiology Authors: Dyavanapalli J Tags: Am J Physiol Heart Circ Physiol Source Type: research