Setting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project

Differentiated thyroid cancer has been treated with radioiodine for almost 80  years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...
Source: EJNMMI Physics - Category: Radiology Authors: Tags: Original research Source Type: research

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A 55-year-old woman with papillary thyroid carcinoma under total thyroidectomy and cervical lymph node dissection was referred for 131I radioiodine therapy. Posttherapeutic whole-body scintigraphy revealed increased focal uptake in the right upper abdomen, which localized to the region of the head of the pancreas on SPECT/CT fusion images. Further evaluation with MRI affirmed the radioiodine retention corresponded to bile duct dilation.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
A 66-year-old man with history of papillary thyroid cancer status post total thyroidectomy underwent 131I-radioiodine ablation. Posttherapy 131I whole-body scan revealed unexpected activity within the left posterior ankle. SPECT/CT localized the radioiodine uptake to a gouty tophus in the Achilles tendon.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
In this study, scintigraphy and single-photon emission computed tomography/computed tomography images after radioactive iodine treatment revealed a physiological uptake of radioactive iodine due to lacrimal secretion around an artificial eyeball; such findings have not been reported previously.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
1630Objectives: To investigate the relationship between cardiac dysfunction and duration of treatment after TSH suppression therapy in elderly high-risk DTC patients. Methods: GSMPI data of elderly high-risk DTC patients with aged 60-64 years from September 2015 to September 2016 at the First Affiliated Hospital of Zhengzhou University were collected. Patients were arranged for GSMPI as a baseline one month after total thyroidectomy, subsequently 131-iodine treatment and TSH suppression treatment were performed. Patients were divided into 2 groups according to the duration of TSH suppression treatment. GSMPI were performed...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Science (Poster Session) Source Type: research
Conclusions: Optimization and standardization of imaging acquisition parameters for diagnostic I-131 planar and SPECT/CT imaging are important for obtaining high quality scans that help guide therapeutic I-131 administration. References:1. Avram AM, Esfandiari NH, Wong KK. Preablation 131-I scans with SPECT/CT contribute to thyroid cancer risk stratification and 131-I therapy planning. J Clin Endocrinol Metab. 2015;100(5):1895-902.2. Avram AM, Fig LM, Frey KA, Gross MD, Wong KK. Preablation 131-I scans with SPECT/CT in postoperative thyroid cancer patients: what is the impact on staging? J Clin Endocrinol Metab. 2013;98(3):1163-71.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
1231Introduction: The sodium/iodide symporter (NIS) protein mediates transport of iodide into cells, and provides a key role in diagnosis and treatment of well-differentiated thyroid cancers. Surprisingly, breast cancer has recently been found to express hNIS in more than 75% of all sampled tumors 1. There is potential for NIS-mediated radiotracer imaging and radioiodide therapy in breast cancer, as it has been performed for decades in thyroid cancer under the same mechanisms. Some pretreatment agents such as retinoids alone or in combination with DEX have been used to enhance NIS expression and activity in breast cancer c...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Oncology & amp; Translational (Poster Session) Source Type: research
49Objectives: Low iodine diet (LID) is an important preparation for radioactive iodine remnant tissue ablation (RIA) for differentiated thyroid cancer. However, strict adherence to LID for a longer period is not easy for patients living in an iodine sufficient area. The aim of this study is to examine whether a LID for two weeks is superior to a LID for one week in decreasing urinary iodine concentration (UIC), which is supposed to be a biomarker for iodine status. Methods: We enrolled 38 patients (M/F 7/26. Age 61.2±14.2yrs.) with post-surgical papillary thyroid cancer with stage II or stage III by TNM classificati...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Spotlights in Endocrinology Source Type: research
Conclusions: 99mTcO4- and [211At]-astatide may be co-administered and individually resolved in a pre-clinical setting for the evaluation tissue uptake and clearance kinetics. The concurrent use of 131I in this context is not recommended without use of a high-energy collimator of suitable specification. This method will provide a detailed evaluation of 99mTcO4- as a clinical surrogate for image-based [211At]-astatide dose prescription for metastatic thyroid cancer.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology (Poster Session) Source Type: research
Conclusions This FASpecT/CT acquisition in radioiodine-treated DTC offers the potential of higher sensitivity for metastatic lymph node detection in low count rates and a significant decrease in imaging time in high count rates. These advantages make SPECT/CT imaging more acceptable for patients who have difficulty with longer imaging times, to include the pediatric population.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Horm Metab Res 2020; 52: 158-167 DOI: 10.1055/a-1111-8927The aim of the study was to evaluate the clinical impact of pre-ablation rhTSH-stimulated fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT in addition to post-therapeutic whole body radioiodine scanning in patients with intermediate to high risk differentiated thyroid carcinoma (DTC). This was a retrospective single center study including 73 patients with thyroid cancer (44 females, mean age 43.2±16.2 years, 62% papillary, 31% follicular, 7% poorly differentiated). All patients underwent ablative radioiodine treatment ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
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