Hedgehog Signaling in Intestinal Development and Homeostasis.

Hedgehog Signaling in Intestinal Development and Homeostasis.
Annu Rev Physiol. 2020 Oct 09;:
Authors: Walton KD, Gumucio DL
Abstract
The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In the embryo, fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally derived epithelium, while signal transduction is confined to the mesenchymal compartment, where at least a dozen distinct cell types are capable of responding to Hh signals. Epithelial Hh ligands not only regulate a variety of mesenchymal cell behaviors, but they also direct these mesenchymal cells to secrete additional soluble factors (e.g., Wnts, Bmps, inflammatory mediators) that feed back to regulate the epithelial cells themselves. Evolutionary conservation of the core Hh signaling pathway, as well as conservation of epithelial/mesenchymal cross talk in the intestine, has meant that work in many diverse model systems has contributed to our current understanding of the role of this pathway in intestinal organogenesis, which is reviewed here. Expected final online publication date for the Annual Review of Physiology, Volume 83 is February 10, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 33035430 [PubMed - as supplied by publisher]

Source: Annual Review of Physiology - October 9, 2020 Category: Physiology Authors: Walton KD, Gumucio DL Tags: Annu Rev Physiol Source Type: research