Assessments of regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration: a transected sciatic nerve model in rat.

Assessments of regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration: a transected sciatic nerve model in rat. Neurol Res. 2020 Oct 09;:1-9 Authors: Ebrahimi-Zadehlou P, Najafpour A, Mohammadi R Abstract PURPOSE: It is compulsory to make a tension-free, end-to-end repair in transected injuries. However, when it comes to longer defects, placement of an autograft or nerve conduits is required. The present study was designed to assess regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rat. METHODS: In NML group left sciatic nerve was exposed through a gluteal muscle incision and after careful hemostasis skin was closed. In TSC group left sciatic nerve was transected and stumps were fixed in adjacent muscle. In CTN group, 10-mm sciatic nerve defects were bridged using a chitosan. In CTN/NSLM group, 10-mm sciatic nerve defects were bridged using a chitosan conduit and 100 µL silymarin nanoparticles were administered into the conduit. The regenerated fibers were studied 4, 8, and 12 weeks after surgery. Assessment of nerve regeneration was based on behavioral, functional, biomechanical, histomorphometric, and immuohistochemical criteria. RESULTS: The behavioral, functional, electrophysiological, and biomechanical studies confirmed significant recovery of regenerated axons in CTN/NSL...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research

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