Repurposing Hepatitis C Direct -acting antivirals against COVID-19

Publication date: Available online 10 October 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Pramod Kumar, Anand Kulkarni, Mithun Sharma, Padaki Nagaraja Rao
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research

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Authors: Lembke A PMID: 33028468 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
Authors: Bonn M, Palayew A, Bartlett S, Brothers TD, Touesnard N, Tyndall M Abstract People who use drugs (PWUD) face concurrent public health emergencies from overdoses, HIV, hepatitis C, and COVID-19, leading to an unprecedented syndemic. Responses to PWUD that go beyond treatment--such as decriminalization and providing a safe supply of pharmaceutical-grade drugs--could reduce impacts of this syndemic. Solutions already implemented for COVID-19, such as emergency safe-supply prescribing and providing housing to people experiencing homelessness, must be sustained once COVID-19 is contained. This pandemic is not o...
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Click arrow to playDownload TWiV 670 (76 MB .mp3, […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology coronavirus COVID-19 influenza virus mRNA-1273 pandemic prefusion conformation respiratory syncytial virus SARS-CoV-2 spike vaccine viral viruses Source Type: blogs
A conversation about the US election and the possible fallout for science, and are maternal behaviours learned or innate?In this episode:00:46 US electionIn the United States the presidential race is underway, and Nature is closely watching to see what might happen for science. We speak to two of our US based reporters to get their insight on the election and what to look out for. News Feature: A four-year timeline of Trump’s impact on science; News Feature: How Trump damaged science — and why it could take decades to recover; News: What a Joe Biden presidency would mean for five key science issues12:36 Coronap...
Source: Nature Podcast - Category: Science Authors: Source Type: podcasts
(Columbia University School of Engineering and Applied Science) Columbia Engineering researchers report that Sofosbuvir-terminated RNA is more resistant to the proofreader of SARS-CoV-2, the virus that causes COVID-19, than Remdesivir-terminated RNA. The results of the new study, published today by the Nature Research journal Scientific Reports, support the use of the FDA-approved hepatitis C drug EPCLUSA--Sofosbuvir/Velpatasvir--in combination with other drugs in COVID-19 clinical trials.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Honour given special resonance in year when world is gripped by coronavirus pandemic
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
(STOCKHOLM) — Americans Harvey J. Alter and Charles M. Rice and British-born scientist Michael Houghton won the Nobel Prize for medicine on Monday for their discovery of the hepatitis C virus, a major source of liver disease that affects millions worldwide. Announcing the prize in Stockholm, the Nobel Committee noted that the trio’s work identified a major source of blood-borne hepatitis that couldn’t be explained by the previously discovered hepatitis A and B viruses. Their work, dating back to the 1970s and 1980s, has helped saved millions of lives, the committee said. “Thanks to their discovery, ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized News News Desk wire Source Type: news
Authors: Pokorska-Śpiewak M, Śpiewak M Abstract In recent years, significant progress in the antiviral treatment of chronic hepatitis C (CHC) has been made due to the development of interferon-free therapies. Three different highly effective, oral direct-acting antiviral (DAA) regimens have been approved for use in adolescents with CHC between the ages of 12-years-old and 17-years-old in Europe. According to the current recommendations, all treatment-naïve and treatment-experienced children with CHC virus infection should be considered for DAA therapy to prevent the possible progression of hepatitis C virus-...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
F, Rizzo LV Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) collection began in two Brazilian hospitals for treatment of severe/critical patients. METHODS AND MATERIALS: Mild/moderate COVID-19 convalescents were selected as CCP donors after reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and absence of symptoms for ≥14 days plus (a) age (18-60 years), body weight greater than 55 kg; (b) immunohematological studies; (c) no infectious markers of hepatitis B virus, ...
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
Many types of viral infections can involve the human cardiovascular, such as Coxsackievirus, parvovirus B19, adenovirus, influenza virus, human herpes virus, Epstein-Barr virus, cytomegalovirus, hepatitis C virus, human immunodeficiency virus (HIV) [1], and even severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is currently circulating worldwide [2]. Zika virus (ZIKV), a type of RNA virus belonging to the family Flaviviridae and genus Flavivirus, was declared a Public Health Emergency of International Concern in February 2016 by the World Health Organization due to the severe damage it causes to the nervous system.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research
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