Clioquinol inhibits dopamine- β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells.

This study suggested that the disturbance of cellular copper transport by the inactivation of ATOX1 is one of the mechanisms involved in clioquinol-induced neurotoxicity in SMON. PMID: 33034664 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33034664?dopt=Abstract

Source: Archives of Toxicology - October 9, 2020 Category: Toxicology Authors: Katsuyama M, Kimura E, Ibi M, Iwata K, Matsumoto M, Asaoka N, Yabe-Nishimura C Tags: Arch Toxicol Source Type: research