Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.
Ageing Res Rev. 2020 Oct 05;:101188
Authors: Parkhitko AA, Filine E, Mohr SE, Moskalev A, Perrimon N
Abstract
Metabolism plays a significant role in the regulation of aging at different levels, and metabolic reprogramming represents a major driving force in aging. Metabolic reprogramming leads to impaired organismal fitness, an age-dependent increase in susceptibility to diseases, decreased ability to mount a stress response, and increased frailty. The complexity of age-dependent metabolic reprogramming comes from the multitude of levels on which metabolic changes can be connected to aging and regulation of lifespan. This is further complicated by the different metabolic requirements of various tissues, cross-organ communication via metabolite secretion, and direct effects of metabolites on epigenetic state and redox regulation; however, not all of these changes are causative to aging. Studies in yeast, flies, worms, and mice have played a crucial role in identifying mechanistic links between observed changes in various metabolic traits and their effects on lifespan. Here, we review how changes in the organismal and organ-specific metabolome are associated with aging and how targeting of any one of over a hundred different targets in specific metabolic pathways can extend lifespan. An important corollary is that restriction or supplementati...

Source: Ageing Research Reviews - October 5, 2020 Category: Genetics & Stem Cells Authors: Parkhitko AA, Filine E, Mohr SE, Moskalev A, Perrimon N Tags: Ageing Res Rev Source Type: research