Can gadoxetic acid-enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?

CONCLUSION: GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis, and could help to avoid liver biopsy in patients with NAFLD. PMID: 33033571 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research

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Conclusions: Higher value in percent increase in FAR is positively associated with higher level of IHTG percent value at 6 months in children with baseline NAFLD. FAR could be a potential biomarker to monitor the changes in IHTG in children with NAFLD.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Background: Currently the treatment of non-alcoholic fatty liver disease (NAFLD) is based on weight loss through lifestyle changes, such as exercise combined with calorie-restricted dieting.Objectives: To assess the effects of a commercially available weight loss program based on a very low-calorie ketogenic diet (VLCKD) on visceral adipose tissue (VAT) and liver fat content compared to a standard low-calorie (LC) diet. As a secondary aim, we evaluated the effect on liver stiffness measurements.Methods: Open, randomized controlled, prospective pilot study. Patients were randomized and treated either with an LC or a VLCKD a...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
To compare the performance of multi-echo chemical-shift-encoded (MECSE) magnetic resonance imaging (MRI) proton density fat fraction (PDFF) estimation, considering three different fat frequency peak combinations, for the quantification of steatosis in patients with non-alcoholic fatty liver disease (NAFLD).
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
Conclusion: This systematic review and meta-analysis will provide evidence to judge whether vitamin D supplementation is an effective intervention for children with NAFLD. Registration number: INPLASY202050049.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
CONCLUSION: The four investigated NAFLD scores performed differently in the populationbased vs high-risk setting. FLI was preferable in the population-based setting, while LFS performed best in the high-risk setting. PMID: 32685107 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Pediatric NAFLD shows unique features of histology and pathophysiology compared to adults. Changes in serum iron parameters are common in adult NAFLD and have been termed dysmetabolic iron overload syndrome characterized by increased serum ferritin levels and normal transferrin saturation; however, the associations of serum ferritin, inflammation, and l...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Lee BW, Lee YH, Park CY, Rhee EJ, Lee WY, Kim NH, Choi KM, Park KG, Choi YK, Cha BS, Lee DH, Korean Diabetes Association (KDA) Fatty Liver Research Group Abstract This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research
This article is a meta ‐analysis that evaluates the efficacy of sodium–glucose cotransporter 2 inhibitors on the treatment of non‐alcoholic fatty liver disease. The results show that sodium–glucose cotransporter 2 inhibitors can significantly decrease alanine aminotransferase and magnetic resonance imaging proto n density fat fraction, accompanied with the reduction of weight and visceral fat areas. We can conclude that sodium–glucose cotransporter 2 inhibitor is a new option to treat non‐alcoholic fatty liver disease in the future. AbstractAims/IntroductionNon ‐alcoholic fatty live...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
The objective of this study was to determine the effects of a moderately CHO ‐restricted diet (CRD) vs fat‐restricted diet (FRD) in adolescents with NAFLD on reduction in liver fat and insulin resistance.MethodsThirty ‐two children/adolescents (age 9‐17) with obesity and NAFLD were randomized to a CRD (50% energy from CHO:protein:fat) or FRD (55:25:20) for 8  weeks. Caloric intakes were calculated to be weight maintaining. Change in hepatic lipid content was measured via magnetic resonance imaging, body composition via dual energy X ray absorptiometry and insulin resistance via a fasting blood sample.Results...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
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