Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Invades Brain.
Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Invades Brain. Intern Med. 2020 Oct 07;: Authors: Morimoto A, Fujioka Y, Ushiku T, Kurokawa M PMID: 33028779 [PubMed - as supplied by publisher]
Publication date: Available online 8 October 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Hayder Saeed, Lubomir Sokol
CONCLUSIONS: SS-associated T cell lymphomas constitute a minority. Treatment with anti-CD20 monoclonal antibody (mAb) and viral infections may be implicated in their pathogenesis. PMID: 33025901 [PubMed - as supplied by publisher]
Epstein –Barr virus (EBV) is associated with the pathogenesis of a variety of malignancies, most notably lymphomas. Especially in the background of immunodeficiency, such as primary immunodeficiency disorder (P...
Extranodal NK/T cell lymphoma (ENKTL) is a rare type of mature T and NK neoplasm. It is more prevalent in Asia and Latin America where Epstein Barr Virus (EBV) is endemic and have been linked to the disease. Most studies have emerged from those two regions to evaluate best management options. There are no standards of care in the management due to lack of unified approach depending on the treatment region and availability of different therapy options. Several reviews have focused on the outcome of the different chemotherapy combinations.
We report a dermatology patient who developed anaphylaxis after receiving extracorporeal photopheresis for the treatment of leukemic mycosis fungoides. We suspect that our patient's anaphylaxis resulted from exposure to an agent used in extracorporeal photopheresis.
AbstractUltraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS and MERS, and SARS-CoV-2, bring back the attention to this therapeutical opportunity. UBI has a complex virucidal activity, mostly acting on the immune system response. It has effects on lymphocytes (T-cells and B-cells), macrophages, monocytes, dendritic cells, low-density...
AbstractThe nasal type of extranodal natural killer (NK)/T-cell lymphoma (ENKL) is an aggressive form of non-Hodgkin ’s lymphoma. Although ENKL is most commonly seen in the midline of the nose, face and Waldeyer's ring, it can also occur in the skin, gastrointestinal tract, soft tissues and other parts of the body. Severe ENKL cases are accompanied by hemophagocytosis, with clinical manifestations such as high f ever, hepatosplenomegaly, and decreased blood cell count. ENKL at different locations exhibits similar histological features and immunophenotypes, such as a strong affinity for T cell markers CD2 and CD56, cy...
Publication date: Available online 5 October 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Leyla Bojanini, Liuyan Jiang, Alexander J. Tun, Ernesto Ayala, David M. Menke, Bradford Hoppe, Mohamed A. Kharfan-Dabaja, Han W. Tun, Muhamad Alhaj Moustafa
Hepatosplenic T-cell Lymphoma (HSTCL) is an aggressive subtype of peripheral T cell lymphoma. Prospective trials providing therapeutic guidance are lacking due to rarity of the disease. We studied the clinical characteristics and therapeutic outcomes of 22 patients with HSTCL. Liver involvement and chronic immunosuppression prior to diagnosis were associated with worse prognosis.