Overexpression of S100A4 protects retinal ganglion cells after retinal ischemia-reperfusion injury in mice.

CONCLUSION: Our results indicated that the neuroprotective effects of overexpressed S100A4 on RGCs by activating Akt pathway and then inhibiting the apoptosis of cells after I/R injury. S100A4 protein may be a novel therapeutic target for glaucoma.
PMID: 33031790 [PubMed - as supplied by publisher]

Source: Experimental Eye Research - October 5, 2020 Category: Opthalmology Authors: Yang J, Yang N, Luo J, Cheng G, Zhang X, He T, Xing Y Tags: Exp Eye Res Source Type: research