The Noninvasive Diagnostic Value of MRN for CIDP: A Research from Qualitative to Quantitative
Conclusions. The nerve roots of CIDP, Charcot-Marie-Tooth disease type-1, and polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome were difficult to distinguish by MRN. Atypical CIDP patients had less nerve root injury compared with typical CIDP patients. MRN of either the brachial plexus or the lumbosacral plexus had a high diagnostic accuracy for CIDP, and it is not necessary to perform both parts of the examination. Level of Evidence: 2
Conclusions: In this dual-center retrospective series, the single-incision triple innominate osteotomy was extremely effective for improving acetabular coverage and stabilizing unstable hips in a variety of underlying diagnoses with an acceptably low rate of complications. Level of Evidence: Level IV—case series.
Condition: Chemotherapy-induced Peripheral Neuropathy Intervention: Drug: Cannabidiol 100 MG/ML Sponsors: Zealand University Hospital; University of Copenhagen Not yet recruiting
ConclusionGanglioside monosialic acid potentially decreases severe utidelone plus capecitabine-induced peripheral neuropathy in metastatic breast cancer, and further investigation is needed to validate the manageable efficacy of GM1 in CIPN.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT02253459.
Peripheral neuropathies including Guillain ‐Barré syndrome may be linked to life‐threatening COVID‐19. Plasma exchange is a safe rescue therapy in severe COVID‐19 with associated neurological manifestations and thromboinflammation. AbstractPeripheral neuropathies including Guillain ‐Barré syndrome may be linked to life‐threatening COVID‐19. Plasma exchange is a safe rescue therapy in severe COVID‐19 with associated neurological manifestations and thromboinflammation.
Discussionby Dr MGK Murthy, Dr GA PrasadChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized clinically by a progressive or relapsing course of many months to years of symptoms similar to compressive myelopathy.Etiology Remains unknown, but T-cell activation in nerves plays an important role in the pathogenesis of CIDP&antigens in Schwann cells have been identified.PathologicallyCIDP is characterized by mononuclear cell infiltrates, edema, segmental demyelination, and remyelination&“onion bulb formation” which describes enlarged fascicles with increased endoneural connectiv...
Conclusions: The PR of all adult NMD in RoI is relatively high when compared with other chronic neurologic disorders, although some figures may be an underestimate of the true prevalence. The data provide a framework for international comparison and service planning.
This study broadens the clinical phenotype of hereditary motor and sensory neuropathy due to MPZ mutation and emphasises the difficulty of achieving an accurate genetic diagnosis in a sporadic patient to provide an appropriate pharmacologic treatment.
A 52-year-old man presented with sudden onset of acral paresthesia and imbalance. The patient did not have any recent illness, sick contacts, or travel abroad. He denied weakness, pain, bowel or bladder incontinence, dysphagia, dysarthria, or shortness of breath. On neurologic examination, 1 month into his symptoms, he had reduced muscle strength in his finger spread, extension, and flexion on both sides graded on Medical Research Council scale 4–/5 and in toe extensors –4/–4 and toe flexors –4/4. The rest of his muscle strength was normal. Reflexes were absent throughout. He had reduced sensation t...
Despite being a literally palpable clinical feature of some peripheral neuropathies, nerve enlargement is rarely studied systematically. Enlarged nerves can often be felt or seen, particularly in the neck, in the hereditary hypertrophic neuropathies, especially in Dejerine-Sottas disease and Charcot-Marie-Tooth disease type 1A (CMT1A). Even in affected children as young as 3 years, the authors have strongly suspected CMT1A when the child, and particularly a parent, has excessively large and easily palpable median nerves at the elbow, which approach or exceed the size of a standard pencil. Nerve hypertrophy is also encounte...