Are Modic Changes Associated With Health-related Quality of Life After Discectomy: A Study on 620 Patients With Two-year Follow-up

Study Design. A registry-based comparative cohort study with 2-year follow-up. Objective. To assess whether Modic changes (MCs) are associated with health-related quality of life, long-term physical disability, back- or leg pain after discectomy. Summary of Background Data. Previous studies have failed to show a clinically significant association between MCs and patient-reported outcomes (PROs) after discectomy. Methods. Data from the Danish National Spine Registry on patients undergoing first-time lumbar discectomy at a single institution from 2014 to 2017 with an accessible preoperative lumbar magnetic resonance imaging, complete preoperative, and 2-year follow-up questionnaires were obtained. PROs including Oswestry disability index (ODI), European Quality of Life—Five Dimensions (EQ-5D), visual analogue scale (VAS) back and leg pain, and patient satisfaction were collected. Patients were stratified based on the presence (+MC) or absence (−MC) of MCs on the preoperative MRI. Results. Of 620 patients included, MCs were present in 290 patients (47%). Of these, MC type 1 (MC-1) was present in 73 (25%) and MC type 2 (MC-2) in 217 (75%) patients. Preoperative data for ODI, EQ-5D, VAS-BP, and VAS-LP were comparable for the +MC and −MC groups. Both groups had a statistically significant improvement in PROs from baseline compared with 2-year follow-up (P 
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research

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Source: Spine - Category: Orthopaedics Tags: CERVICAL SPINE Source Type: research
J Neurol Surg A Cent Eur Neurosurg DOI: 10.1055/s-0041-1725955 Objectives The aim of this retrospective case study was to analyze the outcomes of minimal nerve root retraction in patients with impending neurologic deficit in degenerative lumbar spine disease using the full-endoscopic spine surgery. Materials and Methods Thirty-seven consecutive patients with impending neurologic deficit underwent endoscopic spine surgery through either the transforaminal or the interlaminar approach. Their clinical outcomes were evaluated with visual analog scale (VAS) leg pain score, Oswestry Disability Index (ODI), and Ma...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
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Source: European Spine Journal - Category: Orthopaedics Source Type: research
CONCLUSION: Our results suggest that the blind method is safe for administering CEI to patients with chronic low back pain in the absence of radiological screening and results in significant pain relief with improved functional capacity.PMID:34151825 | DOI:10.3233/BMR-200262
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Authors: Source Type: research
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Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Authors: Source Type: research
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Source: Asian Spine Journal - Category: Orthopaedics Authors: Source Type: research
Conclusions: Statistically and clinically significant improvement in postoperative clinical assessment scores was observed for both lumbar discectomy and transforaminal lumbar interbody fusion groups. MC on preoperative MRI was not associated with worse preoperative or postoperative clinical assessment scores. Level of Evidence: Level III.
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
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Source: Spine - Category: Orthopaedics Tags: CERVICAL SPINE Source Type: research
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profil...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
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