A single-center prospective cohort study on postsplenectomy sepsis and its prevention

This study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis. Methods. From 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ( " early study entry " ) and those who had splenectomy (or were asplenic)>3 months before study entry ( " delayed study entry " ). Results. A total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (P
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

Related Links:

Conclusion(s): Use of an IV push strategy may safely facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance with sepsis management guidelines.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusion(s): Urinary ACR, a cost-effective tool, correlates with the severity of sepsis and associated morbidity and mortality in children.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Objective: The aim of this study was to measure the effects of a bundle of interventions in children admitted with severe sepsis or septic shock in the first hour after diagnosis on mortality. Material(s) and Method(s): A retrospective study was conducted at a pediatric intensive care unit (PICU) between January 2014 and January 2016. Three interventions (intravenous [IV] antibiotic, fluid boluses, and vasopressor administration) applied in the first hour of severe sepsis or septic shock diagnosis were analyzed according to their adherence rates. The main outcome was mortality. Odds ratios were calculated. Result(s): Of a ...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conditions:   Septic Shock;   Coagulopathy;   Disseminated Intravascular Coagulation Interventions:   Drug: OctaplasLG®;   Drug: 0.9% NaCl Sponsor:   University Hospital, Strasbourg, France Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report the association between the new SIGARC score and in-hospital, 30 and 90-day mortality of SS patients cared for in the pre-hospital setting by a mobile ICU (MICU).
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Source: Critical Care - Category: Intensive Care Authors: Tags: Letter Source Type: research
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. I...
Source: Annals of Intensive Care - Category: Intensive Care Authors: Tags: Review Source Type: research
Authors: Conti P, Caraffa A, Gallenga CE, Ross R, Kritas SK, Frydas I, Younes A, Ronconi G Abstract SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and tissue damage that can lead to patient death. These effects are primarily induced by IL-1 cytokines, which are involved in the elevation of hepatic acute phase proteins and fever. IL-1 has a broad spectrum of biological activities and participates in both innate and acquired immunity. In infections, IL-1 induces gene expression and synthesis of several cytokin...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: Hai PD, Phuong LL, Dung NM, Hoa LTV, Quyen DV, Chinh NX, Minh VD, Nguyen Son P Abstract Introduction: Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using speckle-tracking echocardiography. Methods: From May 2017 to December 2018, patients aged ≥18 years adm...
Source: Critical Care Research and Practice - Category: Intensive Care Tags: Crit Care Res Pract Source Type: research
ConclusionsElective stoma closure has significant risk of morbidity. Patients with longer operative times were at increased risk for major morbidity, overall SSI, and reoperation. From the analysis, factors specifically associated with major morbidity, overall infectious complications, readmissions, and reoperations were identified. This information can be used to prospectively prepare for these high-risk patients, potentially improving postoperative outcomes.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
More News: Germany Health | Health | Hospitals | Meningitis Vaccine | Pneomococcal Vaccine | Septic Shock | Splenectomy | Study | Vaccines