Impulsiveness, personality traits and executive functioning in patients with juvenile myoclonic epilepsy

Publication date: Available online 8 October 2020Source: SeizureAuthor(s): André Peres Gama, Mariângela Taura, Neide Barreira Alonso, Artur Menezes Sousa, Maria Helena da Silva Noffs, Elza Márcia Yacubian, Laura Maria Guilhoto
Source: Seizure - Category: Neurology Source Type: research

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Conclusions: The presented CAP algorithm returns increased ablation of the amygdalohippocampal complex, with lower patient risk scores compared to straight-line trajectories. Significance: This is the first clinical application of preoperative planning for steerable needle based LiTT. This study suggests that steerableneedles have the potential to improve - iTT procedure efficacy whilst improving the safety and should thus be investigated further.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
CONCLUSION: Taken together, these correlations among drug resistance, seizure frequency, spatial memory impairment and MFS suggested the possibility of a common pathological mechanism. More studies are needed to clarify the underlying mechanism behind these correlations and the detailed role of MFS in epilepsy. The mechanism of mossy cell change may be an important target for the treatment of seizures, drug resistance and cognitive dysfunction in patients with epilepsy.PMID:34538230 | DOI:10.2174/1567202618666210917155408
Source: Epilepsy Curr - Category: Neurology Authors: Source Type: research
Neurol Neurochir Pol. 2021 Sep 20. doi: 10.5603/PJNNS.a2021.0063. Online ahead of print.ABSTRACTVigabatrin (VGB), a second-generation antiepileptic drug, is effective for the treatment of infantile spasms and focal seizures, primarily in tuberous sclerosis complex (TSC) patients. However, reports of adverse events of VGB, including VGB-associated visual field loss and brain abnormalities in neuroimaging, have raised concerns about the broader use of VGB and thus significantly limited its application. The goal of this review was to summarise the recent therapeutic guidelines, the use of VGB in focal seizures and new VGB app...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Source Type: research
CONCLUSION: Taken together, these correlations among drug resistance, seizure frequency, spatial memory impairment and MFS suggested the possibility of a common pathological mechanism. More studies are needed to clarify the underlying mechanism behind these correlations and the detailed role of MFS in epilepsy. The mechanism of mossy cell change may be an important target for the treatment of seizures, drug resistance and cognitive dysfunction in patients with epilepsy.PMID:34538230 | DOI:10.2174/1567202618666210917155408
Source: Current Neurovascular Research - Category: Neurology Authors: Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0110. Online ahead of print.ABSTRACTThe tRNA methyltransferase 10 homologue A (TRMT10A) gene encodes a tRNA methyl transferase, and biallelic loss of function mutations cause a recessive syndrome of intellectual disability, microcephaly, short stature and diabetes. A case with intellectual disability and distinctive features including microcephaly was admitted. She was diagnosed with epilepsy at 2.5 years old. At 3.6 years of age, severe short stature related to growth hormone deficiency was detected. She had an incidental diagnosis of diabete...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
CONCLUSION: ALFF had high concordance rate with SEEG-defined SOZ at individual-patient level.SIGNIFICANCE: ALFF activation on rsfMRI can add localizing information for the noninvasive presurgical workup of intractable focal epilepsies.PMID:34538574 | DOI:10.1016/j.clinph.2021.07.028
Source: Clinical Neurophysiology - Category: Neurology Authors: Source Type: research
Accurate seizure forecasting is emerging as a near-term possibility due to recent advancements in machine learning and EEG technology improvements. Large-scale data curation and new data element collection through consumer wearables and digital health tools such as longitudinal seizure diary data has uncovered new possibilities for personalized algorithm development that may be used to predict the likelihood of future seizures. The Epilepsy Foundation recognized the unmet need for development in seizure forecasting following a 2016 survey where an overwhelming majority of respondents across all seizure types and frequencie...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Toothbrushing epilepsy is a rare form of reflex epilepsy (RE) with sporadic incidence. To characterize the genetic profile of reflex epilepsy patients with tooth brushing-induced seizures in a Chinese family. Solo clinical whole-exome sequencing (WES) of the proband, a 37-year-old Chinese man, was performed to characterize the genetic etiology of toothbrushing epilepsy. Mutations in the maternal X-linked synapsin 1 (SYN1) identified in the proband and his family members were confirmed by Sanger sequencing. The pathogenicity of these mutations was determined using in silico analysis. The proband had four episodes of toothbr...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Lacosamide is generally safe and well tolerated in patients with epilepsy. Common AEs were sedation, dizziness, and fatigue. It is necessary to pay more attention to the prevention and management of these AEs and conduct more large-scale and high-quality studies to update safety data.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Dipti Kapoor, Divyani Garg, Suvasini SharmaAnnals of Indian Academy of Neurology 2021 24(4):470-480 Ketogenic dietary therapies (KDTs) have been in use for refractory paediatric epilepsy for a century now. Over time, KDTs themselves have undergone various modifications to improve tolerability and clinical feasibility, including the Modified Atkins diet (MAD), medium chain triglyceride (MCT) diet and the low glycaemic index treatment (LGIT). Animal and observational studies indicate numerous benefits of KDTs in paediatric neurological conditions apart from their evident benefits in childhood intractable epilepsy, including...
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
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