Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS

Conclusion This study reveals that GC resistance coincides with preferential CNS recruitment of pathogenic Th17.1 cells, which may hamper the long-term efficacy of GCs in early MS.

http://nn.neurology.org/cgi/content/short/7/6/e894?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - October 9, 2020 Category: Neurology Authors: Koetzier, S. C., van Langelaar, J., Blok, K. M., van den Bosch, T. P. P., Wierenga-Wolf, A. F., Melief, M.-J., Pol, K., Siepman, T. A., Verjans, G. M. G. M., Smolders, J., Lubberts, E., de Vries, H. E., van Luijn, M. M. Tags: Multiple sclerosis Article Source Type: research