Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).

CONCLUSIONS: Altogether, these results demonstrate that Gas1 is a positive regulator of Dhh in ECs while Cdon is a negative regulator. Interestingly, Cdon blocking molecules may then be used to promote endothelium integrity, at least in inflammatory conditions. PMID: 33028094 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33028094?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 8, 2020 Category: Cardiology Authors: Chapouly C, Hollier PL, Guimbal S, Cornuault L, Gadeau AP, Renault MA Tags: Arterioscler Thromb Vasc Biol Source Type: research