Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1.

CONCLUSIONS: TSP1 contributes to aneurysm pathogenesis, at least in part, by suppressing TIMP1 expression, which subsequently enables inflammatory macrophages to infiltrate vascular tissues. PMID: 33028100 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33028100?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 8, 2020 Category: Cardiology Authors: Yang H, Zhou T, Sorenson CM, Sheibani N, Liu B Tags: Arterioscler Thromb Vasc Biol Source Type: research