Cancers, Vol. 12, Pages 2892: Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells

Cancers, Vol. 12, Pages 2892: Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells Cancers doi: 10.3390/cancers12102892 Authors: Stefan Franco Achraf Noureddine Jimin Guo Jane Keth Michael L. Paffett C. Jeffrey Brinker Rita E. Serda Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we show the interplay between macrophages and MSNs from initial uptake to intercellular trafficking to neighboring cells along microtubules. The nature of cytoplasmic bridges between cells and their role in the cell-to-cell transfer of nano-scale materials is examined, as is the ability of macrophages to function as carriers of nanomaterials to cancer cells. Both direct administration of nanoparticles and adoptive transfer of nanoparticle-loaded splenocytes in mice resulted in abundant localization of nanomaterials within macrophages 24 h post-injection, predominately in the liver. While heterotypic, trans-species nanomaterial transfer from murine macrophages to human HeLa cervical cancer cells or A549 lung cancer cells was robust, transfer to syngeneic 4T1 breast cancer cells was not detected in vitro or in vivo. Cellular connections and nanomaterial transfer in vivo were rich among immune cells, facilitating coordinated immune responses.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

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The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo. Chem Pharm Bull (Tokyo). 2020;68(10):962-970 Authors: Feng B, Zhao C, Li J, Yu J, Zhang Y, Zhang X, Tian T, Zhao L Abstract Oleanolic and ursolic acids were used as lead compounds to synthesize a series of pentacyclic triterpenoid derivatives bearing ethylenediamine, butanediamine, or hexanediamine groups at the C-3 position. The potential antiproliferative activity of these compounds was examined in A549 (human non-small cell lung cancer cel...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
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Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
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Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Oncol Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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