Vitamin D – A host directed autophagy mediated therapy for tuberculosis

Publication date: November 2020Source: Molecular Immunology, Volume 127Author(s): Krisna Moorthi Periyasamy, Uma Devi Ranganathan, Srikanth Prasad Tripathy, Ramalingam Bethunaickan
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research

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Yohei Sasakawa – WHO Goodwill Ambassador for Leprosy Elimination and Chairman of Sasakawa Health Foundation speaking at the 3rd of the “Don’t Forget Leprosy” webinar series organized by Sasakawa Health Foundation on Dec 2. Credit: Stella PaulBy Stella PaulHyderabad, Dec 3 2021 (IPS) As 2021 nears its end, public health systems worldwide remain severely strained by COVID 19, which is showing no sign of ending. But even as countries battle to control the deadly pandemic, they must also maintain the progress made against other diseases, including leprosy, global leprosy experts and advocates have urged...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: COVID-19 Editors' Choice Featured Global Health Human Rights Humanitarian Emergencies Inequity TerraViva United Nations #Sasakawa IPS UN Bureau leprosy Source Type: news
SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
The host immune system plays a pivotal role in the containment of Mycobacterium tuberculosis (Mtb) infection, and host-directed therapy (HDT) is emerging as an effective strategy to treat tuberculosis (TB), especially drug-resistant TB. Previous studies revealed that expression of sirtuin 7 (SIRT7), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, was downregulated in macrophages after Mycobacterial infection. Inhibition of SIRT7 with the pan-sirtuin family inhibitor nicotinamide (NAM), or by silencing SIRT7 expression, promoted intracellular growth of Mtb and restricted the generation of nitric oxide (NO)...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Approximately one-fourth of the global population is latently infected with Mycobacterium tuberculosis. An understanding of the burden of latent tuberculosis infection (LTBI) among immigrants compared with the ge...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Lipid droplets (LDs) are commonly found in various biological cells and are organelles related to cell metabolism. LDs, the number and size of which are heterogeneous across cell type, are primarily composed of polar lipids and proteins on the surface with neutral lipids in the core. Neutral lipids stored in LDs can be degraded by lipolysis and lipophagocytosis, which are regulated by various proteins. The process of LD formation can be summarized in four steps. In addition to energy production, LDs play an extremely pivotal role in a variety of physiological and pathological processes, such as endoplasmic reticulum stress...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
[MBC] The 2021 World Health Organisation Global Tuberculosis Report has revealed that for the first time in over a decade TB deaths have increased globally because of reduced access to TB diagnosis and treatment in the face of the COVID-19 pandemic.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Source: Journal of Inflammation Research - Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
CONCLUSIONS: This study is one of only a few analyses of hospitalised patients with DILI in SA. Among those with severe DILI, outcomes are poor, the majority cannot tolerate standard regimens, and mortality is high.PMID:34852891 | DOI:10.7196/SAMJ.2021.v111i5.15353
Source: South African Medical Journal - Category: African Health Authors: Source Type: research
CONCLUSIONS: The globalisation trend is evident in the clinical trials business, but cannot be generalised to all emerging countries. Timing and intensity vary from country to country relative to factors that advance the existing profit-orientated business models of the sponsors. Furthermore, various diseases have been localised, which entails a diversely increasing need for research.PMID:34852888 | DOI:10.7196/SAMJ.2021.v111i5.14870
Source: South African Medical Journal - Category: African Health Authors: Source Type: research
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