Invasion of poorly differentiated large-cell neuroendocrine tumor of the lung through right pulmonary veins into the left atrium: A very rare case report.
Invasion of poorly differentiated large-cell neuroendocrine tumor of the lung through right pulmonary veins into the left atrium: A very rare case report. J Clin Ultrasound. 2020 Nov;48(9):560-564 Authors: Nosrati A, Nabati M, Vahedi L, Shokri M Abstract Intracavitary cardiac metastasis is a rare manifestation of primary lung cancer which can be associated with a very poor prognosis. In this condition, the right chambers of the heart are more commonly involved and the invasion of the left atrium (LA) through the venous routes is highly exceptional. Poorly differentiated large-cell neuroendocrine tumors also include only 3% of all primary lung carcinomas which can have adverse outcomes. Therefore, in this report, a rare case of a 72-year-old male patient with poorly differentiated large-cell neuroendocrine carcinoma of the right lung spreading to the LA through the right pulmonary veins was described. PMID: 33031570 [PubMed - as supplied by publisher]
In this report, both patients had lung mass accompanied by cough that lasted for>2 weeks, and were admitted to hospital for further diagnosis and treatment to clarify the nature of the mass. To make a definite diagnosis, EBUS-TBNA examination was performed under general anesthesia. Both patients had no salient past history. Diagnosis: Case 1 was diagnosed as tumor or pneumonia based on the right lung shadow. Case 2 was diagnosed with squamous cell carcinoma of the right lung with right hilar lymph node metastasis. The diagnostic results of both patients were based on pathological examination of tissues obtained by EB...
Conclusions: Percutaneous US-guided MWA is safe and effective in terms of local control and survival of adrenal metastasis.
CONCLUSION: In selected patients, neoadjuvant therapy with ICI is well tolerated and can induce a complete remission of the tumor. Treatment with ICI has no negative impact on the surgical procedure. Prognosis seems to be promising in CPR and limited in PPR. PMID: 32820489 [PubMed - as supplied by publisher]
Psammoma bodies are concentrically lamellated structures made of calcium that are frequently observed in the setting of papillary carcinoma of the thyroid and serous papillary adenocarcinoma of the ovary .
Pulmonary carcinoids are well-differentiated neuroendocrine carcinomas of the lung and are classified as either low-grade (typical carcinoids [TCs]) or intermediate-grade (atypical carcinoids). These tumors account for only 1 –2 % of primary lung malignancies, although the incidence is increasing. [1,2] Given the rarity of these tumors, data on their diagnosis, staging, and treatment are lacking; hence, recommendations are generally derived from those for non-small cell lung cancer .
Conclusion Anlotinib effectively controlled the growth of NSCLC and improved TAO related symptoms. Anlotinib maybe normalize disordered growth of blood vessels through the VEGF signaling pathway, rather than simply inhibiting angiogenesis. DOI: 10.3779/j.issn.1009-3419.2020.01.10
A 63-year-old man was referred to us for evaluation of an asymptomatic mass in the left lower lung. Three weeks earlier, he had inadvertently found a painless swelling on his left neck, for which he had been recommended to have a physical screening, and during which the lung mass had been detected. He was a heavy smoker without any significant medical history. Physical examination was unremarkable other than a well-circumscribed lymph node measuring 2.1 cm × 1.4 cm in the upper left neck. Positron emission tomography/computed tomography (PET/CT) demonstrated 18F-fluorodeoxyglucose (FDG) signific...
Conclusion: Some cases of ICC may be responsive to the antiangiogenic drug, anlotinib, when combined with microwave ablation. Randomized clinical studies are required to further confirm the efficacy and safety of anlotinib in the clinical treatment of ICC.
Introduction: The EBUS-TBNA is a minimally invasive technique widely used in the diagnosis, staging and immunohistochemistry analysis of lung cancer.1PDL-1 is a checkpoint on NSCLC that can be targeted with immunotherapy.2Routine PDL-1 testing was introduced at Oxford University Hospital NHS Foundation Trust (OUHFT) in 2017 and it is unclear if EBUS-TBNA provides adequate tissue for testing. In our current practice at the OUHFT, all NSCLC cases (Squamous Cell Lung Carcinoma and Lung Adenocarcinoma) identified on cytopathology are subsequently tested for PDL-1 tumour percentage score (TPS). The aim of this study was to see ...
Conclusion: EBUS-TBNA has a high NPV for lung cancer staging, confirming that this endoscopic technique is safe and effective in the preoperative staging. In this setting, a low risk negative LNs might not need further confirmation by mediastinoscopy.